Description

StressDoctor – is a complex of natural components capable of exerting a mild calming effect, restoring mood balance, and improving the functional state of the nervous and cardiovascular systems:
• Increases resistance to psychological and stress tension,
• Helps reduce anxiety, prevents the development of depression,
• Stimulates mental abilities and restoration of cognitive functions,
• Prevents age-related memory deterioration,
• Improves the process of falling asleep.

Scientifically proven properties of the components*:

Choline
Choline must be obtained from the diet, as endogenous synthesis is insufficient to meet the body’s needs; α-glycerylphosphorylcholine is a water-soluble form of choline.
Choline performs important and diverse functions in neurotransmission, membrane synthesis, lipid transport, and carbohydrate metabolism. Choline preserves the energy reserve of neurons and stimulates the synthesis of acetylcholine. Adequate intake and/or supplementation of choline is considered important for healthy brain function, behavior, has a positive effect on memory, and may help older adults recover it after impairment.
Choline and its metabolites (phosphatidylcholine) are important for maintaining the structural integrity of cell membranes, remodeling synaptic connections, modulating neuron morphology, and neurotransmission. Choline is involved in the biosynthesis of structural components of neuron membranes (phospholipids), which is confirmed by magnetic resonance spectroscopy data. It ensures the functioning of membrane ion-exchange pumps, the modulation of which is necessary for the normal conduction of nerve impulses.
Choline is considered a “neuroprotective” and “important neurocognitive nutrient” that is essential for the normal growth and function of the brain. Experimental studies have shown that choline inhibits the activation of certain phospholipases (A1, A2, C, and D), reduces the formation of free radicals, prevents the destruction of membrane systems, and preserves antioxidant defense systems such as glutathione.
Choline contributes to improved cognitive functions, prevents age-related memory decline and neurological changes. Choline improves attention and awareness levels, including in cognitive and neurological disorders (1,2,3,4).

Magnesium
Magnesium is involved in metabolic reactions of energy formation, accumulation, transport and utilization, regulation of cell membrane state (exchange of calcium and sodium ions), and the synthesis of neurotransmitters.
Magnesium deficiency is accompanied by increased mental and physical fatigue under normal loads, a feeling of depression due to inadequate energy utilization.

γ-Aminobutyric acid (GABA)
GABA is an amino acid known as the main inhibitory neurotransmitter in the central nervous system. Its physiological role is related to the modulation of synaptic transmission, promotion of neuron development and relaxation, and prevention of insomnia and depression. It has been proven that GABA helps maintain activity, memory, as well as brain cognitive functions, especially in the elderly. GABA promotes mental concentration and stimulates physical and mental abilities.

B vitamins
Supplemental intake of vitamins B1 and B6 replenishes inadequate dietary intake and ensures the body has the necessary amount of coenzymes. B vitamins are components of enzyme systems that regulate the metabolism of proteins, fats, and carbohydrates. However, each B vitamin has a specific biological role (5-9).

Vitamin B1 (thiamine)
Thiamine is necessary for many physiological functions, including glucose metabolism, maintenance of nerve membrane function, synthesis of myelin and neurotransmitters acetylcholine and serotonin, as well as amino acids. A more important function of thiamine, as a cofactor for carbohydrate conversion, is its promotion of cellular energy metabolism to supply nerve cells with energy.
Thiamine is indirectly necessary for the synthesis of nucleic acids, neurotransmitters, and myelin, thus it contributes to nerve conduction speed. Thiamine is also a coenzyme of enzymes essential for the normal functioning of the digestive tract, cardiac activity, and endocrine glands.

Vitamin B6
Vitamin B6 (pyridoxine) participates in over 140 coenzyme systems. It has important functions in the synthesis of neurotransmitters: dopamine from L-DOPA (L-3,4-dihydroxyphenylalanine), serotonin from 5-HTP (5-hydroxytryptophan), and gamma-aminobutyric acid (GABA) from glutamate. Thus, pyridoxine affects adrenergic, serotonergic, and glutamatergic systems and plays a vital role in tryptophan metabolism. Pyridoxine exhibits a neuroprotective role attributed to its ability to regulate glutamatergic systems (since GABA is the main inhibitory and glutamate the excitatory neurotransmitter).
Coenzyme forms of pyridoxine are necessary for the metabolism of homocysteine, proteins, carbohydrates, and fats, as well as the synthesis of sphingolipids and, hence, are important for the formation of nerve cell myelin.
To date, there is no data on carcinogenic, mutagenic, or teratogenic properties of vitamins B1 and B6.

Glycine
Glycine is an amino acid in the human body. Glycine acts as a precursor of several key metabolites: creatine (energy storage in muscles), glutathione, heme (oxygen transport in blood), purines, and porphyrins. Glycine also improves sleep quality and neurological functions. It modulates certain neuropeptides in the central nervous system, which can indirectly contribute to reducing drowsiness and fatigue caused by sleep restriction, as well as improve sleep quality in people with sleep issues.

Consumption recommendations:
StressDoctor may be recommended as a dietary supplement to the diet as an additional source of choline, vitamins B6, B1, magnesium, amino acids glycine and γ-aminobutyric acid. The effective combination of ingredients supports the normal functional state of the nervous and cardiovascular systems, enhances resistance to psychological and stress tension, and contributes to mental balance and mood stability.

The ingredients of StressDoctor product contribute to the support of:
• normal functioning of the central and peripheral nervous systems, including in cases of physical and/or mental fatigue caused by increased psycho-emotional stress;
• recovery of normal cognitive functions, including in the elderly or after illnesses;
• normal sleep onset and improved sleep quality;
• reduction of anxiety and/or relaxation;
• normal blood glucose and cholesterol levels.

Choline supports normal nerve impulse transmission, participates in the biosynthesis of structural components of neuron membranes, supports cognitive functions, helps preserve memory and brain functions, and supports heart health.
Vitamins B1, B6, and magnesium contribute to the reduction of fatigue and tiredness, the normal function of the nervous system, and mental activity.
Glycine is a building block for structural and functional proteins in the body, is a component of the antioxidant glutathione, is involved in the synthesis of heme (blood oxygen transport), creatine (muscle energy storage), and provides the primary structure for glucose synthesis.

Recommended daily portion – 10 ml contains:
Choline (from α-glycerylphosphorylcholine) – 243 mg
Magnesium (from magnesium citrate) – 60 mg
γ-Aminobutyric acid – 250 mg
Vitamin B6 – 2 mg
Vitamin B1 – 1.5 mg
Glycine – 500 mg

Composition: purified water, α-glycerylphosphorylcholine (choline alfoscerate), glycine, magnesium citrate, γ-aminobutyric acid, acidity regulator (malic acid), preservative (sodium benzoate), pyridoxine hydrochloride, thiamine mononitrate, flavoring.

Warnings:
Not recommended for use in case of individual hypersensitivity to the main components, under the age of 18. Pregnant or breastfeeding women, the elderly, or individuals with any medical conditions should consult a doctor before use. This product is not intended for diagnosis, treatment, or prevention of any disease and should not be used as a substitute for a full diet. Do not exceed the recommended daily dose. Do not use a solution from damaged packaging. Do not use after the expiry date indicated on the packaging.
Consultation with a doctor is mandatory before use.

Not a medicinal product.

Method of consumption and recommended daily amount:
Adults – 10 ml per day after meals or as recommended by a doctor.
The daily portion can be diluted in a small amount of water or consumed without water.

Duration of use: duration should be agreed upon with a doctor.

Minimum shelf life: best consumed before the end of the date indicated on the packaging; shelf life – 24 months from the production date.
Batch (series) number: indicated on the packaging.

Storage conditions: store in a dry place, protected from light, and out of reach of children at a temperature not exceeding 25 °C. Use within 6 months after opening.

Form of release: oral solution, 200 ml in a container with a measuring cup in a cardboard box.

Manufacturer (market operator responsible for food product information):
JUSV “Sperco Ukraine” LLC. 21027, Ukraine, Vinnytsia, 600-richia str., 25,
Phone: +38 (0432) 523-049

Country of origin: Ukraine
Barcode: indicated on the packaging

List of references*:

1. Dietary Reference Values for choline EFSA Journal2016;14(8):4484
2. Lippelt DP, vander Kint S, vanHerk K, Naber M. No Acute Effects of Choline Bitartrate Food Supplements on Memory in Healthy, Young, Human Adults. PLoS One. 2016 Jun 24;11(6):e0157714. doi: 10.1371/journal.pone.0157714. PMID: 27341028; PMCID: PMC4920398.
3. Wiedeman AM, Barr SI, Green TJ, Xu Z, Innis SM, Kitts DD. Dietary Choline Intake: Current State of Knowledge Across the Life Cycle. Nutrients. 2018 Oct 16;10(10):1513. doi: 10.3390/nu10101513. PMID: 30332744; PMCID: PMC6213596.
4. Chin EWM, Goh ELK. Modulating neuronal plasticity with choline. Neural Regen Res. 2019 Oct;14(10):1697-1698. doi: 10.4103/1673-5374.257516. PMID: 31169177; PMCID: PMC6585560
5. https://compendium.com.ua/info/339274
6. Jong-HoPark J.H., Saposnik G., Ovbiagele B., Markovic D., Towfighi A. Effect of B-vitamins on stroke risk among individuals with vascular disease who are not on antiplatelets: A meta-analysis//Int J Stroke.2016 Feb;11(2):206-11. doi: 10.1177/1747493015616512.
7. https://compendium.com.ua/akt/67/2636/cyanocobalaminum
8. https://compendium.com.ua/akt/80/2873/pyridoxinum
9. https://compendium.com.ua/akt/84/2771/thiaminum

characteristics of the dietary supplement “StressLikar” (DS):
Composition: purified water, α-glycerylphosphorylcholine (choline alfoscerate), glycine, magnesium citrate, γ-aminobutyric acid, acidity regulator (malic acid), preservative (sodium benzoate), pyridoxine hydrochloride, thiamine mononitrate, flavoring.
Form of release: oral solution, 200 ml in a container with a measuring cup in a cardboard box.
Properties:
StressDoctor may be recommended as a dietary supplement to the daily diet as an additional source of choline, vitamins B6, B1, magnesium, the amino acids glycine and γ-aminobutyric acid. The effective combination of ingredients supports the normal functional state of the nervous and cardiovascular systems, enhances resistance to psychological and stress tension, and promotes mental balance and mood stability.
Name and location of the market operator (consumer claims department): JUSV “Sperco Ukraine” LLC. 21027, Ukraine, Vinnytsia, 600-richia str., 25, tel/fax: +38 (0432) 52 30 49.

Report of the SE “Scientific Center for Preventive Toxicology, Food and Chemical Safety named after Academician L. I. Medved of the MOH of Ukraine”, No. 3/28-A-963-23-432 dated 08.06.2023.
©2023 JUSV “SPERCO UKRAINE” LLC. All rights reserved.